Objectives To explore the relationship of RDW level with the blood pressure level and cardiac function.
Methods A total of 130 in-hospital patients with essential hypertension was enrolled in hypertension group, which from Guangzhou First People’s Hospital during July 2012 to September 2012, it was divided into 3 groups according to the blood pressure level [grade 1 hypertension group (n = 29), Grade 2 hypertension group (n = 47), Grade 3 hypertension group (n = 54)], 82 healthy volunteers with normal blood pressure were assigned to the control group. Blood samples were collected for routine blood test. Doppler echocardiography was applied to measure Left ventricle ejection fraction (EF) and Mitral ratio of peak early to late diastolic filling velocity (E/A), which can reflect the cardiac function. The SPSS 13.0 software was used for statistical analysis. Two groups comparisions were tested by Independent-samples t test. Multiple comparisions were tested with one-way ANOVA. The dependablity analysis was tested by non-parametric Spearman correlation.
Results RDW levels were significantly increased in hypertension group compared with the control group (P < 0.001). RDW was positively related to hypertension grade (r = 0.365, P < 0.001), however, RDW was not correlated with either the EF or E/A ratio (P < 0.05).
Conclusions RDW levels were increased in the patients with essential hypertension, which may predict the severity of hypertension. but there were no correlation between RDW and cardiac function, The role of RDW in cardiovascular disease need further investigation.