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GW24-e2117 Acipimox attenuates atherosclerosis and enhances plaque stability in ApoE-deficient mice fed a palmitate-rich diet
  1. Ma Shuangtao,
  2. Feipeng Jin,
  3. Sihua Jiang,
  4. Dachun Yang,
  5. De Li,
  6. Yongjian Yang
  1. Department of Cardiology, General Hospital of PLA Chengdu Military Area Command, Chengdu, Sichuan 610083, PR China

Abstract

Objectives Saturated fatty acids (FA) have been linked to an increased risk of cardiovascular disease. The effects of acipimox, a FA-lowering agent, on palmitate- (an important saturated fatty acid) stimulated atherosclerosis remains to be elucidated.

Methods We investigated the effects of acipimox on atherosclerosis in ApoE-/- mice fed a palmitate-rich diet. Male ApoE-/- mice, 6 to 8 weeks of age, were randomised into three groups. The animals were fed a normal chow diet in the control group, a diet containing 5% palmitic acid in the palmitate group, and a diet containing 5% palmitic acid and 0.02% acipimox in the acipimox group. The plasma lipid profiles, aortic lesions, plaque collagen content and the expression of matrix metalloproteinase (MMP-2, MMP-3, MMP-9, and MMP-14) and the tissue inhibitor of MMP (TIMP-1, and TIMP-2) were determined after a 12-week treatment.

Results The palmitate-rich diet significantly increased plasma FA concentrations (P < 0.01), enhanced atherosclerotic lesions (P < 0.01), decreased plaque collagen content (P < 0.01) and upregulated MMP-2 (P < 0.05) in the aorta. Additionally, all of these harmful effects were significantly attenuated by co-treatment with acipimox (P < 0.05 or P < 0.01).

Conclusions The present study suggests that acipimox attenuates atherosclerosis and enhances plaque stability in ApoE-/- mice fed a palmitate-rich diet.

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