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GW24-e2932 Clinical research on the relationship between day-night rhythm
  1. Shan HaiYan1,
  2. Li Xue-lian2,
  3. Yu Kai1,
  4. Qi Hui-meng1
  1. 1Department of Gerontology, The First Affiliated Hospital of China Medical University
  2. 2School of Public Health, China Medical University

Abstract

Objectives To study the relationship between day-night rhythm and hypersensitive C-reactive protein (hs-CRP), urinary microalbumin (MAU) in elderly patients with essential hypertension (EH).

Methods According to the blood pressure-decreasing ratio in 24 hours ambulatory blood pressure monitor (24h ABPM), 76 elderly patients with EH were divided into dipping group (n = 31) and non-dipping group (n = 35). hs-CRP, MAU in these patients were examined at the same time.

Results The plasma level of hs-CRP in non-dipping group was significantly higher than that in the dipping group [(6.98 ± 1.34) mg/L vs (3.58 ± 1.02) mg/L, P < 0.01)]. The level of MAU in non-dipping group was significantly higher than that in the dipping group [(22.09 ± 3.18) mg/L vs (12.46 ± 2.69) mg/L, P < 0.01]. Linear correlation analysis showed that there was a positive relationship between nSBP and hs-CRP, MAU (r = 0.426, P < 0.01; r = 0.258, P < 0.01) in elderly patients with non-dipper essential hypertension.

Conclusions Day-night rhythm in elderly patients with non-dipper EH is closely correlated with inflammation factor, MAU.

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