Objectives To observe the effectiveness and safety of calcitriol intervention to mild to moderate essential hypertension with vitamin D deficiency.
Methods 103 patients were newly diagnosed as mild-moderate essential hypertension with vitamin D deficiency in the first teaching hospital of Xinjiang Medical University from September 2012 to March 2013. They were divided into observation group (53 cases) and control group (50 cases) randomly. Patients of observation group took calcitriol and nifedipine GITS, control group patients took nifedipine GITS only. The two groups both checked 25-hydroxyvitamin D, blood pressure, heart rate, renin-angiotensin-aldosterone level, serum calcium, serum phosphate, urea and serum creatinine before the treatment and after 4 weeks treatment,12 weeks treatment, 24 weeks treatment.
Results After the treatment, the basic line of vitamin D of two groups rose apparently, the level of systolic pressure and diastolic pressure was obviously declined (P < 0.01). The level of renin of control group patients was dramatic declined compared with the basic line (P < 0.05). Compared with control group, observation group patients. After 12 weeks treatments, 24 weeks treatments, the level of renin, angiotensin were obviously declined (P < 0.05), and after 24 weeks treatments, the systolic pressure of observation group patients declined more than control group (P < 0.05).
Conclusions Blood pressure of mild to moderate essential hypertension with vitamin D deficiency can be obviously reduced after taking calcitriol, especially systolic pressure, it is possibly that the increasing of vitamin D can depress renin-angiotensin-aldosterone system.