Objectives To study the relationship between renal function and left ventricular hypertrophy (LVH) in patients with refractory hypertension (RH), and to investigate the relative risk factors of LVH in RH patients.
Methods 215 (120 cases of RH and 95 cases of none RH) hospitalised patients were retrospectively analysed. The renal function was evaluated by modification of diet in renal disease (MDRD) formula, and 24h ambulatory blood Pressure were monitored. Echocardiography measurement were performed, and left ventricular mass index (LVMI) were calculatled. LVH were definited when LVMI > 125 g/m2 in male or LVMI > 110 g/m2 in female.
Results Compared with that in none RH group, estimated glomerular filtration rate (eGFR) in RH group was lower [(72.3 ± 22.1) vs (83.1 ± 19.5) ml/(min.1.73m2), P < 0.01], while the detectable rates of eGFR < 60 ml/(min.1.73m2), LVH, secondary hypertension, and LVMI in RH group were higher [29.2% vs 10.5%, 32.5% vs 16.8%, 31.7% vs 5.3%, (108.0 ± 27.1) vs (95.3 ± 22.9) g/m2, respectively]. These differences had statistic significance (all P < 0.05). The logistic regression analysis showed that OR value of eGFR < 60 ml/(min.1.73m2) and concomitant hypercholesteremia were 4.5 (95%CI 1.82-1.07, P = 0.001) and 3.6 (95%CI 1.36-9.58, P = 0.010), respectively.
Conclusions Renal function and LVH are evident in RH patients. Different levels of renal function had different impacts on LVH. eGFR<60 ml/(min.1.73m2) is a relative risk factors of LVH.