Objectives To analyse the prevalence, risk factors and target organs damage of female hypertensive diabetic patients. To assess the 5-year cumulative hypertensive incidence and cardiocerebrovascular events after 5 years followed up.
Methods The combination methods of retrospective and prospective analysis was applied to carried out the study in the Kailuan corporation from 2006 to 2007. 1580 female diabetic patients were selected as the research object. The prevalence, risk factors and target organs damage of those patients were analysed. They were followed up for five years and the cumulative hypertensive incidence and cardiocerebrovascular events were assessed. Excel software was applied for databases and SPSS13.0 software was applied for statistical analysis.
Results 547 case of 1580 female diabetic subjects had hypertension (HT) and the hypertensive prevalence was 36.4%. Results of single factor analysis revealed that the prevalence of HT in single and married women was 49.0% vs 33.6%, in the individuals whose educational background below junior middle school and above senior middle school was 32.2% vs 45.5%, in not snoring and snoring patients was 23.9% vs 50.6%. Their difference were significant (P < 0.01). The mean age, body mass index (BMI), levels of triglyceride (TG), low-density lipoprotein cholesterol (LDL-chol), serum uric acid, serum creatinine (Cr) of normotensive group and hypertensive group was 54.7 ± 9.2 vs 60.6 ± 8.5 years old, 26.0 ± 3.9 vs 27.4 ± 3.7 Kg/m2, 2.1 ± 1.7 vs 2.4 ± 1.8 mmol/L, 2.3 ± 0.9 vs 2.5 ± 1.0 mmol/L, 243.3 ± 73.5 vs 283.7 ± 87.1 umol/L, 80.1 ± 23.8 vs 87.7 ± 25.2 umol/L, Respectively. Their difference were significant (P < 0.01). Results of multiariable logistic regression analysis showed that ageing, snore, and the increase in BMI, TG and LDL-chol concentration, serum uric acid and Cr levels were the risk factors for female hypertensive diabetic patients. The prevalence of myocardial infarction (MI), cerebral infarction, cerebral haemorrhage and renal insufficiency in normotensive and hypertensive group was 0.9% vs 5.5%, 0.8% vs 9.5%, 0.3% vs 1.1% and 15.2% vs 23.4% respectively. Their difference were significant (P < 0.01). After 5-year follow-up, 54.6% of all participants suffered from HT. The new cases of HT was 316 and the cumulative hypertensive incidence was 30.59%. The 5-years incidence of cerebral infarction in normotensive and hypertensive diabetic group was 1.5% and 3.7% respectively. The difference were significant (P < 0.01).
Conclusions Ageing, snore, and the increase in BMI, TG and LDL-chol concentration, serum uric acid and Cr levels were risk factors for of female hypertensive diabetic patients. HT was the risk of target organs damage including MI, stroke and renal insufficiency in female diabetic patients. The 5-year incidence of cerebral infarction in female hypertensive diabetic patients was notable higer than that without HT. We should further strengthen integrated control of risk factors in female hypertensive diabetic patients to improve the prognosis and reduce the incidence of cardiocerebrovascular events.