Objectives CytochromeP450 4A11 (CYP4A11) and CYP4F2 are responsible for renal production of 20-hydroxyeicosatetraenoic acid (20-HETE), a metabolite involved in the regulation of blood pressure. Essential hypertension (EH) is considered a typical polygenic disease, so the evaluation of gene–gene interactions rather than the determination of single gene effects is crucial to understanding any genetic influences. The purpose of this study is to explore the interaction between CYP4A11 and CYP4F2 polymorphisms in essential hypertension in a Han Chinese population.
Methods We carried out a case-control study of 861 hypertensive and 664 control subjects recruited from northwestern Chinese Han population The CYP4A11 and CYP4F2 genotypes were determined by using the TaqMan® SNP Genotyping Assay.
Results For men, the CYP4A11CC genotype was significantly more prevalent in patients with EH (P = 0.028). The distributions of alleles and genotypes of the CYP4F2 polymorphisms were not found to be significantly associated with hypertensive status in either total, men or women. In analysis of gene–gene interaction, we found that there was a significant interaction between the CYP4A11CC and CYP4F2GA genotypes in total and men (P = 0.008, P = 0.004, respectively). Multiple logistic regression analysis showed that interaction between the CYP4A11CC and CYP4F2 GA genotypes was an independent risk factor for total and men, total (OR5.21, 95% confidence interval (CI) 1.17-13.16; P = 0.03), men (OR 9.19, 95% CI 1.81-16.49; P = 0.034).
Conclusions A significant interaction between the CYP4A11 CC and CYP4F2 GA genotypes may contribute to the predisposing effect for the development of EH in Han Chinese population.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.