Objectives Arterial stiffness is an independent predictor for vascular diseases. Cardio-ankle vascular index (CAVI) is a new index of arterial stiffness independent of immediate blood pressure. In the present study, we investigated the possible risk factors involving CAVI in hypertension subjects.
Methods 375 male subjects from Shougang Corporation examination centre were enrolled into our study. They were divided into two groups: normal group (n = 233), hypertension group (n = 142). The VS-1000 was used to measure CAVI. Carotid-femoral pulse wave velocity (CFPWV) was detected by the Complior apparatus. Status of abdominal aortic arteriosclerosis was detected by CT angiography. Retinal artery arteriosclerosis was detected by direct ophthalmoscope.
Results The value of CAVI was higher in hypertension subjects than in healthy group (8.15 ± 1.15 vs 7.66 ± 1.00, p < 0.001). The level of CAVI was increased in subjects with abdominal aortic or retinal artery arteriosclerosis than that of normal arteries (8.59 ± 0.52 vs 7.74 ± 0.98, p < 0.001; 8.38 ± 0.86 vs 7.60 ± 0.95, p < 0.001). CAVI was positively correlated with age, CFPWV, SBP, DBP, PP, TG, HbA1c in the entire study group (r = 0.578, 0.480, 0.236, 0.115, 0.249, 0.131, 0.226, respectively, all p < 0.05). Multivariate analysis showed that age, HbA1c were significant independent associating factors of CAVI in all subjects (β = 0.508, p < 0.001; β = 0.189, p = 0.010).
Conclusions CAVI was higher in hypertension subjects, and it was a reliable evaluation index of arterial stiffness of macro- and micro-vascular complication.