Objectives To evaluate the effect of ageing on the changes of structure and function of artery in elderly senile patients with essential hypertension.
Methods Patients (Aged 60-80) were divided into three groups. Meanwhile, all above 195 cases hypertensive patients were divided according to duration of hypertension into four sub-groups. The change of coronary artery (left and right) of all those patients were tested the following index by 64 coronary CT scan. The 24 h systolic blood pressure and other blood biochemical parameters of all patients were also assayed.
Results Then, we found that the value of BMI, TC and LDL were lower, but age and HDL were higher in group of very elderly with hypertension (Group I) (p < 0.05) than those in group of elderly with hypertension (Group III). Both CSLAD, TCS, PP and CSLM, CSLCX, PP were significantly increased in Group I than those in Group III (P < 0.01 and P < 0.05, respectively). Besides, the value of 24h SBP of Group I was higher than in very elderly without hypertension (Group II).
Conclusions Hence, in elderly patients, accompany ageing, there may be a decreasing trend in the levels of BMI, HDL, TC and LDL. Meanwhile, the decline of arterial compliance and increase of arterial stiffness developed with ageing. Ageing is more likely lead to atherosclerosis in coronary artery, especially in the left main coronary and its main branches. Ageing is an uncontrolled risk factor, which had played a crucial role in coronary artery atherosclerosis. Therefore, it is a priority to anti-oxidize and prevent senility.