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GW24-e2187 Effect of fenofibrate and pioglitazone on PPAR-α and PPAR-γ in rats with metabolic syndrome
  1. Luo Yumei,
  2. Guo Hong Bo
  1. LongGang Campus of The People Hospital on Shenzhen

Abstract

Objectives To explore the effect on rats with metabolic syndromes (MS) taking pioglitazone and fenofibrate.

Methods Building a SD rat model of metabolic syndrome (MS) with feeding high-fructose diet, by intervention with single PPAR-α/γagonists FEN, PIO or combined both. Analyse the differences between expression indicators of PPAR-α, PPAR-γ in those MS rats.

Results Expression levels of PPAR-αmRNA, PPAR-γmRNA and protein in the rat aorta were reducing compared with the MC group intervention with FEN and PIO. Intervention combined with FEN and PIO, the expression levels of PPAR-αmRNA and protein were reduced more obviously compared the drugs alone, PPAR-γmRNA and protein expression were similar to intervention with PIO.

Conclusions Intervention of FEN, PIO and combination both, the MS rat aortic expression of PPAR-α/γ were significantly inhibited. Combination were more significantly inhibited the expression of PPAR-α than alone.

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