Article Text

PDF
GW24-e0320 Efficacy of intravenous recombinant human brain natriuretic peptide and noninvasive ventilation in treating the patients with acute decompensated heart failure
  1. Liu Chunyan,
  2. Yu Yuetian
  1. Department of Intensive Care Unit, Shanghai Minghang District Central Hospital, Shanghai 201199 China

Abstract

Objectives To investigate the efficacy and safety of intravenous infusion recombinant human brain natriuretic peptide (rhBNP) with noninvasive ventilation (NIV) in treating patients with decompensated acute heart failure. To investigate the efficacy and safety of intravenous infusion recombinant human brain natriuretic peptide (rhBNP) with noninvasive ventilation (NIV) in treating patients with decompensated acute heart failure.

Methods One hundred and twelve cases admitted to the hospital from January 1, 2010 to December 31, 2012 were retrospective reviewed, and their age, gender, past medical history, NT-proBNP, Oxygenation Index, time of NIV were recorded. Depending on whether the rhBNP was used,all the patients were devided into the drug group (DG) and the compare group (CG). NT-proBNP, Oxygenation Index and time of NIV in each group were compared. According to the results of multivariate regression analysis, drew the fitting curve,and analysed the relativity between the variance ratio of NT-proBNP, Oxygenation Index and the time of NIV.

Results Multivariate regression analysis showed that age [odds ratio (OR) = 1.174, 95% confidence interval (95%CI) 1.797 to 1.910, P = 0.001], variance ratio of NT-proBNP (OR = 1.363, 95%CI 1.936 to 2.358, P = 0.035), variance ratio of oxygenation Index (OR = 2.088, 95%CI 1.273 to 1.847, P = 0.011) were correlated to the time of NIV. The fitting curve of the variance ratio of NT-proBNP and the time of NIV showed linear correlation (r = -0.893, P = 0.012), the variance ratio of oxygenation Index and the time of NIV also showed linear correlation (r = -0.631, P = 0.023) by the fitting curve.

Conclusions Intravenous recombinant human brain natriuretic peptide and noninvasive ventilation are efficient and safe at the early stage of acute decompensated heart failure. They may decrease the time of NIV and may improve the outcome of the patients.

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.