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GW24-e0244 The changes of heart function and NT-proBNP after advanced echo-guided cardiac resynchronisation therapy in patients with heart failure
  1. Guang Xue-feng1,
  2. Dai Hai-long1,
  3. Zuo Ming-xian1,
  4. Gai Qi-ming1,
  5. Ding Cheng-yan1,
  6. Ding Yun-chuan1,
  7. Wang Qing-hui1
  1. 1Department of Cardiology, Yan’an Affiliated Hospital of Kunming Medical University, Yunnan Cardiovascular Hospital

Abstract

Objectives To abserve the changes of heart function and NT-proBNP after advanced echo-guided cardiac resynchronisation therapy in patients with heart failure, and investigate the correlation of left ventricular ejection fraction (LVEF) and the serum level of NT-proBNP.

Methods 1) Control group (20 cases), chronic heart failure with a widened QRS complex (12 cases) and chronic heart failure with a shortening QRS durasion (10 cases) were selected. We evaluated mechanical dyssynchrony with the DTI, the STI and the RT-3DE. 2) The concentrasion of NT-proBNP in serum have been test in Preoperation and postoperative 3 months. 3) To abserve the correlation of the improvement degree of heart function and NT-proBNP in serum level.

Results 1) In CHF groups (including narrow QRS group and broad QRS group), the mean levels of serum NT-proBNP were higher than control group (2372(3169.5–950.25), 2451.5(2765-1574.3) vs 46.8(133.9–30.5), P < 0.05). 2) In preoperation, the serum concentrasion of NT-proBNP showed no statistically significant difference between the narrow QRS group and the broad QRS group (2372(3169.5–950.25) vs 2451.5(2765-1574.3), P > 0.05). 3) In CHF groups (including narrow QRS group and broad QRS group), the serum levels of NT-proBNP in preoperation were greater more than them in postoperation (2372(3169.5–950.25) vs 371.5(553-231.5);2451.5(2765-1574.3) vs 477(646.5–320.5), P < 0.05). 4) In postoperation, the concentrasion of NT-proBNP in the serum showed no statistically significant difference between the narrow QRS group and the broad QRS group(371.5(553-231.5) vs 477(646.5–320.5), P > 0.05). 5) In CHF groups (including narrow QRS group and broad QRS group), the 6 minutes walk test were improved in postoperation (167.9 ± 21.62 vs 256.3 ± 93.92; 162.83 ± 23.26 vs 268.15 ± 89.45, P < 0.05). 6) There are significant negative correlations between the LVEF and the level of Serum NT-proBNP (r = -0.606 P<0.001).

Conclusions Heart failure patients (including narrow QRS) can be benefited from CRT by new echocardiography screening.

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