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Cardiovascular Disease Clinical Research
Heart failure
GW24-e3765 A Correlational Study about Relationship between ACE Gene Polymorphisms with Heart Failure in Hainan Han Nationality.
  1. Zheng Lei1,2,
  2. Liu Zheng Wang1,3,
  3. Wang Ming Jun1,2,
  4. Yun Meiling1
  1. 1Hainan Medical College Hospital
  2. 2Guiyang College of Traditional Chinese Medicine
  3. 3Hainan Provincial Hospital of Traditional Chinese Medicine

Abstract

Objectives To study the correlation between angiotensin converting enzyme (ACE)gene polymorphisms with heart failure in Hainan Han Nationality.

Methods ACE I/D gene polymorphisms were detected by polymerase chain reaction (PCR) in 150 cases of heart failure patients and 150 cases of healthy person from Hainan Han nationality, and the genotype frequencies and allele frequencies of DD, DI and II were investigated.

Results There were no significant differences in the frequencies of allele and genotypes between the healthy subjects and patients with heart failure of Han nationality. There were no significant differences between the two groups (P > 0.05).

Conclusions I/D polymorphism of the ACE gene was not related to heart failure in Hainan Han nationality patients, and was not associated with lipid levels in Hainan Han nationality patients with hypertension.

Key words ACE gene; Polymorphisms; Heart failure.

https://doi.org/10.1136/heartjnl-2013-304613.629

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