Article Text

GW24-e0431 Diagnostic value of 320-slice computed tomography angiography in coronary artery stenosis: A meta-analysis
  1. Liao Xue-wen,
  2. Tan Meng-wei,
  3. Li Li
  1. Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University


Objectives To evaluate the diagnostic accuracy of 320-slice computed tomography coronary angiography (320-SCTA) compared with the standard reference conventional coronary angiography (CCA) in the detection of significant coronary artery stenosis (≥ 50%).

Methods Relevant studies from December, 2005 to April, 2012 were systematically searched, reviewed and included according to appropriate criteria. Diagnostic accuracy of 320-SCTA was evaluated by the pooled resultes of per-segment, per-vessel, and per-patient analysis, respectively. Meta-regression was employed to explain study heterogeneity.

Results Twenty-eight studies were eligible for this study. In per-segment analysis (n = 13351), pooled sensitivity, specificity, LR +, and LR- were 88.1% (95% CI, 86.5%–89.6%), 97.6% (95% CI, 97.3%-97.8%), 36.2 (95% CI, 28.6–45.9) and 0.11 (95% CI, 0.08–0.16), respectively. In per-vessel analysis (n = 2085), the pooled outcomes of sensitivity, specificity, LR +, and LR- were 87.7% (95% CI, 84.4%–90.5%), 95.4% (95% CI, 94.2%-96.4%), 17.4 (95% CI, 13.9–21.8), and 0.13 (95% CI, 0.07–0.20), respectively. In per-patient analysis (n = 1412), corresponding results were sequentially 95.8% (95% CI, 93.1%–97.7%), 89.2% (95% CI, 85.7%-92.1%), 7.4 (95% CI, 5.6–9.6) and 0.08 (95% CI, 0.05–0.13). The area under the summary receiver operating characteristic curve (AUC) in the per-segment, per-vessel, and per-patient analysis were 0.990, 0.983 and 0.960, respectivity. Percentage of unassessable segments had significant influence on heterogeneity (P = 0.03).

Conclusions The excellent diagnostic performance of 320-SCTA may enable it as an alternative to CCA for the detection of coronary artery stenosis.

Statistics from

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.