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GW24-e1368 Effect of atorvastatin on endothelium-dependent relaxation of small pulmonary arteries in monocrotaline-induced PAH rats
  1. Jiang Zhi1,
  2. Liangdi Xie2
  1. 1First Hospital of Longyan
  2. 2Fujian Hypertension Research Institute, First Affiliated Hospital of Fujian Medical University

Abstract

Objectives To examine the preventive effect of atorvastatin on acetylcholine (Ach)-induced endothelium-dependentrelaxation (EDdR) in small pulmonary artery (SPA) rings in monocrotaline (MCT)-inducedpulmonary hypertension rats.

Methods 72 MaleSD rats were randomly assigned into four groups: normal control (Ctr), pulmonaryarterial hypertension (PAH), PAH preventively treated with 5 mg/kg/d (Lator)and 10 mg/kg/d (Hator) atorvastatin respectively. Rats were sacrifiedat the end of 1st, 2nd and 4th wks after administration. Mean pulmonary arterypressure (mPAP), right ventricular hypertrophy index (RVHI%), and vasomotion function were determined. The potency of vascular relaxation was expressed as the pD2 value.

Results mPAP in PAH was significantly higher than that in Ctr 4 wks after MCT injection (32.19 ± 0.91 vs 14.39 ± 0.35, p < 0.01). While preventively treated with atorvastatin for 4 wks, mPAP was significantly decreasedin Lator andHator group as compared with PAH group (19.13 ± 1.01, 17.55 ± 0.20vs 32.19 ± 0.91; p <0.01). RVHI% was significantly decreased after 4 wks preventively treated with atorvastatin in Lator and Hator group compared with PAH group (36.09 ± 4.29 vs 56.76 ± 5.86; 28.93 ± 5.08 vs 56.76 ± 5.86, p < 0.01). Ach-induced EDdR of SPA rings in PAH was not significantly decreased 1 week afterMCT injection, yet markedly decreased 2 weeks after MCT injection (5.81 ± 0.87 vs 8.33 ± 0.86, p < 0.01). There were no differences in Ach-induced EDdRin SPA rings among Ctr, Lator and Hator rats after 1 week or 2 wks preventively treated with different doses of atorvastatin. However, Ach-inducedEDdR in Lator and Hator rats was decreased 4 wks after the preventive treatment (6.51 ± 0.99, 6.41 ± 0.56vs 8.33 ± 0.86, p <0.05).

Conclusions Earlypreventive treatment with low dose of atorvastatin has protective effects onthe early damage of endothelium-dependent vasodilatation function in smallpulmonary artery of MCT-induced PAH rats.

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