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GW24-e1812 Comparative study on clinical efficacy of intravenous injection with Cedilanid, Propafenone, and Amiodarone to control with instantly ventricular rate of fast supraventricular arrhythmia
  1. Wei Xiaojun,
  2. Xie Dongming,
  3. Liao Wei,
  4. Xie Dongyang
  1. Department of Cardiology, The First Affiliated Hospital of Gannan Medical College, Ganzhou

Abstract

Objectives To compare clinical efficacy of intravenous injection with Cedilanid, Propafenone, and Amiodarone to control with instantly ventricular rate of fast supraventricular arrhythmia.

Methods 98 patients with fast supraventricular arrhythmia were chosen from various kinds of heart disease. They were randomly divided into Cedilanid group (32 cases), Propafenone group (31 cases), and Amiodarone group (35 cases). All of cases were excluded contraindications of medication. The dose of drug in three groups was respectively applied with 0.4mg (total less than 0.8mg), 1.0-1.5mg/kg (total less than 210 mg), 100-150 mg (total less than 450mg), which was added in 5%GS 10∼20ml and slowly injected within 10-15min. Continuous ECG and blood pressure were monitored before, during and after the process of medication. It was considered effectiveness when supraventricular arrhythmia turned to sinus rhythm, ventricular rate were below 100bpm or ventricular rate was decreased more than 25%.

Results Patients turning to sinus rhythm after treatment in three groups, were respectively 3,6 and 8 cases. The ventricular rate below 100bpm in three groups was respectively 15, 9 and 14 cases. The ventricular rate decreased more than 25% in three groups was respectively 10, 11 and 8 cases. The effective power was respectively 87.5%, 83.9% and 85.7% in three groups. The average ventricular rate decreased about 30.7%, 29.1% and 27.8% after treatment in 3 groups. There were no un-happened intolerable side effects caused by medication.

Conclusions Intravenous injection with Cedilanid, Propafenone, and Amiodarone to control with instantly ventricular rate of fast supraventricular arrhythmia are reliable efficacy, and have no significant difference among them. It is safe, effective and rapid to control fast ventricular arrhythmias with them and can be used as first-line drugs.

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