Objectives To explore the incidence and affecting factors of LVH in CKD3-5 patients.
Methods 270 CKD3-5 patients were enrolled from Departmnt of nephrology, 3rd hospital of Sun yat-sen University in this study from 2010 to 2012, ambulatory blood pressure monitoring and clinical blood pressure, ultrasonography, proteinuria, and other clinical data were collected.
Results 46.67% CKD patients with LVH, which male accounted for 39.74% and female accounted 52.38%, female group have more LVH patients than male group (P = 0.014). There are 25.0% CKD3 patients, 44.9% CKD4 patients and 53.6% CKD 5 patients with LVH respectively, which have significant difference among the three groups (P < 0.05). LVH group have higher iPTH, BMI, P, Scr, LVMI, P, PP, LVDd, LVPWT, LVST, higher clinic SBP, ambulatory SBP and DBP, day and night SBP and DBP (p < 0.05) and have lower eGFR, HGB, Ca and EF value (p < 0.05) compare with non LVH group. Multivariate linear analysis indicated that BMI, iPTH and night SBP are independently associated with LVMI. Multivariate Logistic regression analysis show BMI, Ipth and day and night SBP are independent risk factors of LVH.
Conclusions LVH are common complication of CKD3-5 patients; BMI, iPTH and ambulatory SBP are independent risk factors of LVH.