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GW24-e3052 Ultrasonographic evaluation over the hypercomplex wavelet on the change of vortex-mediated vascular endothelial cadherin
  1. Zhao Juan1,
  2. Jin Jing2,
  3. Huang Da-yang1,
  4. Zhang Xing-tong1,
  5. Yang Jin-mei1,
  6. Qu Xiu-fen1,
  7. Tian Ye1
  1. 1First Affiliated Hospital, Harbin Medical University, Harbin
  2. 2Department of Control Science and Engineering, Harbin Institute of Technology, Harbin

Abstract

Objectives Ultrasonogram treated by hypercomplex wavelet transform (HWT) can maintain the image spectral characteristics,integrate spatial information and effectively avoid the flow of image noise; however, the evaluation of the flow shear stress (FSS) in the vortex is no report so far in ultrasonogram by HWT.

Methods The research objects were selected in Jan 2013 to April 2013 from the first affiliated hospital of Harbin medical university, which consisted of 30 carotid artery stenosis patients (CAS) and 20 normal cases (Con). The cholesterol, triglycerin, blood sugar, and urine routine were examined within 24 hours before administration. Serum sVE-cad and ICAM levels were measured by ELISA (eBioscience, USA). At the same time, the FSS in carotid arteries was evaluated by HWT.

Results No significant difference were found in the age distribution among the two groups (p = NS). The change of blood flow in the CAS group was significantly increased in comparison with the Con group. Compared with the Con group, the sVE-cad and ICAM levels in the CAS group were rapidly elevated (t = 3.895, P = 0.003; t = 5.112, P = 0.001). However, the apoA level in the Val group was reduced markedly (t = 2.543, P = 0.023) in comparison with that in the Con group.

Conclusions The vortex may cause vascular endothelial cadherin (VE-cad) and intercellular adhersion molecule (ICAM) massively disrupted and Apolipoprotein A (apoA) deposition in endothelial cells. The change of VE-cad and ICAM proteins also reveal the damage degree of vortex-induced ECs, thus verifying the evaluation value of HWT ultrasonogram on flow vortex.

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