Objectives The aim of the present study was to analyse the association between levels of leptin and metabolic syndrome (MS) and the components of MS in Xinjiang Uygur Population.
Methods A total of 781 individuals were selected from the cross-sectional study of MS from Hetian area in Xinjiang Uygur Autonomous Region, aged from 30 to 70 years, included 403 MS subjects and 378 non-MS controls, 249 men and 532 women. All subjects underwent a medical examination and fasting blood measurement, including blood pressure (BP), height, weight, waist circumference (WC), serum leptin, glucose, HDL-cholesterol and triglycerides (TG), et al.
Results No association was found between leptin and MS in the general population. levels of serum leptin were higher in women than men (about 2.9 times) . Levels of serum leptin were significant higher in MS group than non-MS controls in men, but not women. Linear correlation analysis indicate that leptin in men were significantly positive correlated with TG, body mass index (BMI), WC and diastolic blood pressures (DBP). Multiple linear stepwise regression analysis revealed that leptin was independently positive related to TG (β = 0.371) and BMI (β = 0.301) .
Conclusions Elevated leptin levels were significantly associated with MS in men, and leptin was positive correlated with TG, BMI independently, but not in women. Leptin are likely to be an important role in the progression of MS in male Uygur population.