Objectives The aim of our study is to assess left ventricular regional systolic function in patients with hypertrophic cardiomyopathy (HCM) using real-time three-dimensional echocardiography (RT-3DE).
Methods RT-3DE was performed in 25 HCM patients and 20 healthy subjects. The left ventricular volume-time curves were analysed quantitatively with Tomtec 4D LV-Analysis 3.0, and regional left ventricular end diastolic/systolic volume (rEDV/rESV), the time to minimum systolic volume (rESVT), regional stroke volume (rSV), regional ejection fraction (rEF), regional-global ejection fraction (rgEF) and the parameters of left ventricular dyssynchrony were measured.
Results In HCM group, Tmsv16-Dif, Tmsv16-SD, Tmsv16-Dif%, Tmsv16-SD% were significantly reduced than those of normal group (P < 0.01), and rEDV, rSV, rEF and rgEF in hypertrophic segments were lower than those in non-thickening and mild-thickening segments (P < 0.05). In normal group, there were no significant difference in those parameters among all segments (P > 0.05). Compared with normal group, rEDV, rSV and rgEF in hypertrophic segments were decreased in HCM group (P < 0.05). rEF in hypertrophic segments were decreased at basal level but increased at apical level, however, no difference was found at midventricular level; rEF and rgEF in non-thickening and mild-thickening segments were increased (P < 0.05).
Conclusions RT-3DE could sensitively detect left ventricular dyssynchrony and accurately assess regional left ventricular volume and function of different segments.