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GW24-e0649 Assessment of left ventricular regional systolic function in patients with hypertrophic cardiomyopathy by real-time three-dimensional echocardiography
  1. Min Pei,
  2. Qing Lv
  1. Department of Ultrasonography, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology

Abstract

Objectives The aim of our study is to assess left ventricular regional systolic function in patients with hypertrophic cardiomyopathy (HCM) using real-time three-dimensional echocardiography (RT-3DE).

Methods RT-3DE was performed in 25 HCM patients and 20 healthy subjects. The left ventricular volume-time curves were analysed quantitatively with Tomtec 4D LV-Analysis 3.0, and regional left ventricular end diastolic/systolic volume (rEDV/rESV), the time to minimum systolic volume (rESVT), regional stroke volume (rSV), regional ejection fraction (rEF), regional-global ejection fraction (rgEF) and the parameters of left ventricular dyssynchrony were measured.

Results In HCM group, Tmsv16-Dif, Tmsv16-SD, Tmsv16-Dif%, Tmsv16-SD% were significantly reduced than those of normal group (P < 0.01), and rEDV, rSV, rEF and rgEF in hypertrophic segments were lower than those in non-thickening and mild-thickening segments (P < 0.05). In normal group, there were no significant difference in those parameters among all segments (P > 0.05). Compared with normal group, rEDV, rSV and rgEF in hypertrophic segments were decreased in HCM group (P < 0.05). rEF in hypertrophic segments were decreased at basal level but increased at apical level, however, no difference was found at midventricular level; rEF and rgEF in non-thickening and mild-thickening segments were increased (P < 0.05).

Conclusions RT-3DE could sensitively detect left ventricular dyssynchrony and accurately assess regional left ventricular volume and function of different segments.

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