Objectives To assess the systolic dyssynchrony of left ventricular (LV) wall in patients with chronic heart failure (CHF) and different QRS duration by real-time three-dimensional speckle tracking imaging (RT-3DSTI).
Methods The study included sixty-one patients with CHF, 31 with QRS duration <120 ms as CHF1 group and 30 with QRS duration ≥120 ms as CHF2 group, and 53 normal controls. The RT-3DSTI data sets obtained from all subjects were analysed to evaluate LV dyssynchrony by the standard deviation of time from the onset of QRS complexes to peak systolic area, radial, circumferential and longitudinal strain for 16 segments related to heart cycle (Tsas-SD%, Tsrs-SD%, Tscs-SD% and Tsls-SD% ) as well as the maximal temporal difference for each of the components of the LV deformations in 16 segments (Tsas-diff, Tsrs-diff, Tscs-diff and Tsls-diff).
Results Compared with the controls, all of the systolic dyssynchrony indexes (Tsas-SD, Tsrs-SD, Tscs-SD, Tsls-SD, Tsas-diff, Tsrs-diff, Tscs-diff and Tsls-diff) in CHF1 group and CHF2 group increased, and except the Tsls-diff in CHF1 group, the rest of the indicators in CHF1 group and CHF2 group were significantly higher (P <0.01). Compared with CHF1 group, all of the systolic dyssynchrony indexes (Tsas-SD, Tsrs-SD, Tscs-SD, Tsls-SD, Tsas-diff, Tsrs-diff, Tscs-diff and Tsls-diff) in CHF2 group increased significantly (P <0.01∼0.05).
Conclusions CHF patients with narrow QRS durations have LV systolic dyssynchrony, but the systolic dyssynchrony indexes were lower than in CHF patients with wide QRS durations. RT-3DSTI might offer a new rapid method to accurately evaluate LV systolic dyssynchrony.