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GW24-e3795 Effect Of Carvedilol on Left Ventricular Function in Hypertension Patients with the Normal Configuration using Bull'S Eye Chart Pararameters of Real-Time Hee-Dimensional Echocardiography
  1. Wang ZhiYun1,2,
  2. Mei Zhang2,
  3. Yun Zhang2,
  4. Xiao-hua Dai2,
  5. Hong-yun Wang2,
  6. Liang Chen2,
  7. Yuan-xing Xie1,
  8. Ying Liu1,
  9. Zhen-chuang Xi1
  1. 1Affiliated Hospital of Shandong Academy of Medical Sciences
  2. 2Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health; Department of Cardiology, Qilu Hospital, Shandong University

Abstract

Objectives To analyse the changes of bull's eye chart parameters by real-time three-dimensional echocardiography before and after treatment of Carvedilol for 6 months in hypertension patients with normal configuration. In order to evaluate effect of Carvedilol on left ventricular function by the parameter of excursion of left ventricular wall motion in the patients.

Methods 62 patients in hypertension with normal configuration were investigated by real-time three-diametional echocardiography, in order to quantitatively analyse the distance and time of the excursion. All above images were stored for off-line analysis with the dedicated QLAB workstation and all mechanical parameters were collected, then the result of the parameters of excursion of left ventricular wall motion at different time of before and after treatment of Carvedilol for 6 months were compared and studied.

Results The maximum distance (Emax), minimum distance (Emin) and the standard difference (Esd) of the excursion after treatment ofCarvedilol for 6 months were significantly increased than those before treatment of Carvedilol (all P<0.01), and the average percentage of R – R the time required of excursion (E%) was lower than that before treatment (P < 0.05).

Conclusions Thedistance and time of excursion could early quantitatively evaluate the effect of Carvedilol on cardiac function in patients with normal configuration and provide accuracy information to prevent or delay the ventricular remodelling. So, Carvedilol therapy for patients with hypertension could not only make the blood pressure lower, but also reduce the damage of target organ at the same time, which have a significant effect to early protect the cardiovascular system.

Acknowledgements This work was supported by The National Basic Research Program of china (also called 973 Program) 2006CB503803, HI-TECH Technique and Development Program of China (863 Program) 2007AA02Z448 and Natural Science Foundation Program of Province ZR2010HM084.

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