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GW24-e2974 Elevated Serum levels of TNF-alpha in Patients with diastolic dysfunction and Hepatitis C Virus Infection
  1. Che Wenliang1,
  2. Hu Dayi2
  1. 1Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072 China
  2. 2Heart Center, Peking University People's Hospital, Beijing 100044 China

Abstract

Objectives Prior study showed HCV-infected patients exhibited evidence of left ventricular diastolic dysfunction (LVDD), but its pathophysiology remains incompletely understood. We sought to evaluate the relationship between TNF-α and LVDD in HCV-infected patients.

Methods A total of 120 HCV-infected patients and 120 control healthy individuals were enrolled and examined for circulating TNF-α.

Results Serum TNF-α level was significantly higher in patients group (5.67 ± 1.64 pg/mL vs. 2.23 ± 1.26 pg/mL; P <0.001). After adjusting for confounding factors, TNF-α was still associated with NT-proBNP in patients group (β′ = 0.037, P = 0.046). Simple regression analysis demonstrated a correlation between TNF-α vs. E/E′ (r = 0.114, P = 0.024), TNF-α vs. E/A (r = 0.023, P = 0.047), and TNF-α vs. DT (r = 0.148, P< 0.001). Patients with E/E′ ratio > 15, classified as LVDD, had higher TNF-α (7.4 pg/mL vs. 3.2 pg/mL P < 0.001) compared to those with normal diastolic function (E/E′ < 8). In a multivariate regression analysis adjusting for all the factors associated with LVDD, TNF-α was still significantly associated with LVDD (OR: 2.4, 95% CI: 1.34∼2.17, P < 0.001).

Conclusions We found increased serum levels of TNF-α were associated with LVDD in HCV-infected patients, which suggest a link between inflammation and the presence of LVDD.

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