Objectives Prior study showed HCV-infected patients exhibited evidence of left ventricular diastolic dysfunction (LVDD), but its pathophysiology remains incompletely understood. We sought to evaluate the relationship between TNF-α and LVDD in HCV-infected patients.
Methods A total of 120 HCV-infected patients and 120 control healthy individuals were enrolled and examined for circulating TNF-α.
Results Serum TNF-α level was significantly higher in patients group (5.67 ± 1.64 pg/mL vs. 2.23 ± 1.26 pg/mL; P <0.001). After adjusting for confounding factors, TNF-α was still associated with NT-proBNP in patients group (β′ = 0.037, P = 0.046). Simple regression analysis demonstrated a correlation between TNF-α vs. E/E′ (r = 0.114, P = 0.024), TNF-α vs. E/A (r = 0.023, P = 0.047), and TNF-α vs. DT (r = 0.148, P< 0.001). Patients with E/E′ ratio > 15, classified as LVDD, had higher TNF-α (7.4 pg/mL vs. 3.2 pg/mL P < 0.001) compared to those with normal diastolic function (E/E′ < 8). In a multivariate regression analysis adjusting for all the factors associated with LVDD, TNF-α was still significantly associated with LVDD (OR: 2.4, 95% CI: 1.34∼2.17, P < 0.001).
Conclusions We found increased serum levels of TNF-α were associated with LVDD in HCV-infected patients, which suggest a link between inflammation and the presence of LVDD.
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