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GW24-e2961 A summary and evaluation of the current evidence for traditional Chinese medicine for myocardial infarction
  1. Wang Yue1,
  2. Lu Xiao1,
  3. Wei Mu1,
  4. Jingbo Zhai1,
  5. Shuo Zhang1,
  6. Xiao Sun2,
  7. Dongmei Xing1,
  8. Hongcai Shang3
  1. 1Evidence-based Medicine Center of Tianjin University of Traditional Chinese Medicine
  2. 2Tianjin University of Traditional Chinese Medicine
  3. 3Tianjin University of Traditional Chinese Medicine, Research Institute of Chinese Medicine

Abstract

Objectives A comprehensive summary and evaluation of the current evidence profile of the role of traditional Chinese medicine (TCM) in myocardial infarction management was conducted to provide evidence-based recommendations for clinical application and evoke thoughts for future researchers.

Methods We systematically searched CNKI, VIP, CBM, PubMed and the Cochrane Library for literature on TCM for myocardial infarction. After screening, studies were categorised in terms of type into five levels, i.e. systematic review (SR), randomised controlled trial (RCT), observational study, case study and basic research. General information was abstracted, and quality of these studies and conclusions made were summarised and assessed.

Results A total of 452 studies involving 10 SRs, 123 RCTs, 47 observational studies, 28 case studies and 244 basic researches were included.

Clinical studies centred primarily on herbal decoction and most were not rigorously performed. High quality studies were predominantly on patent drugs such as Danshen injection, Shenmai injection, Shengmai injection and Qishen Yiqi dripping pills.

A summary of findings from systematic reviews and clinical research show that TCM may reduce mortality, decrease risk for complication, reduce myocardial injury, improve cardiac function and inhibit ventricular remodelling. Results of experimental studies also support the active role of TCM in reducing infarct size and myocardial injury, promoting angiogenesis, preventing ventricular remodelling and improving cardiac function. According to the current bodies of evidence, TCM has proven effects in the prevention and treatment of myocardial infarction.

It is also found that the effects of Chinese patent drugs vary with indications. For instance, Shenmai injection has been observed especially effective for reducing incidence of acute clinical events, and patent drug with qi-nourishing and blood-circulating properties has been proved good at inhibiting ventricular remodelling.

High-quality evidence supports the use of TCM injection for acute myocardial infarction and Chinese patent drug medication for secondary prevention.

Reports on adverse events and other safety outcomes associated with Chinese medicine are not many.

Conclusions Firstly, sufficient evidence has been drawn from all five types of studies in relation to the use of TCM as an adjuvant to conventional Western medicine for prevention and treatment of myocardial infarction. Scientific and rational use of TCM in combination with western medicine is therefore recommended, taking into consideration of the stage of the disease and therapeutic goals of the patients. For example, herbal decoction and Qishen Yiqi dripping pills are recommended for patients recovering from a myocardial infarction and for secondary prevention, whereas for patients with acute myocardial infarction Shenmai injection would be a good choice. Secondly, the quality of the bodies of evidence remains to be enhanced, and improvements can be made from the following aspects: 1) Some significant research subjects are worthy of further exploration, such as the benefits of and potential risks posed by the concomitant use of Chinese medicine and western drugs with cardiovascular protective properties; 2) The quality of both original and secondary research need to be enhanced, 3) Highlights should be given to the monitoring and reporting of adverse events associated with the use of Chinese medicine; and 4) To promote standard reporting of TCM clinical research.

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