Objectives To study the effects of Bushenhuoxue Herbs on cerebral neurotransmitters in Parkinson’s patients.
Methods In the double-blinded clinical trial, sixty patients were randomised into two groups with 30 in each. The treatment group was treated with Bushen Huoxue Herbs and the control group was with placebo, twice a day. Both groups were taking western medicine as basic treatment. The observation was carried out for 3 months. The follow-up was of 6 months after the treatment cause. Using encephalofluctuography (EFG) to measure the changes of Ach and DA in both groups at baseline time, 3, 6 and 9 months later to evaluate the effects of Bushen Huoxue Herbs.
Results In the control group, DA level decreased and Ach level increased gradually after the treatment for 9 months, but there was no statistical difference (P > 0.05). In the treatment group, DA level increased in the treatment observation period and follow-up with statistical difference (P < 0.05). Ach level didn’t changed. No adverse effects were found in this trial.
Conclusions The level of DA has being reduced a long with the progress of PD. Ach level increased at the same time. Bushen Huoxue Herbs can increase the level of DA in the brain of PD patients with reliable effects.