Objectives The aim of this study was to investigate the presence of nonalcoholic fatty liver disease (NAFLD) in women with polycystic ovary syndrome (PCOS) and insulin resistance (IR).
Methods Thirty-six women with PCOS diagnosed by the Rotterdam criteria and twenty age- and weight-matched healthy controls were studied. All women have a history of no or minimal alcohol consumption. Anthropometric variables, biochemical and hormonal parameters were determined. NAFLD was evaluated by abdominal ultrasonography and biochemical testing, after excluding causes of secondary liver disease. Insulin resistance was assessed by homeostasis model assessment of insulin resistance (HOMA-IR). Differences were assessed between PCOS and controls using t tests.
Results PCOS patients had an increased prevalence of NAFLD [12/36 patients (33.33%) versus 3/20controls (15%), P < 0.05]. HOMA-IR levels was higher in PCOS with NAFLD than those in control women and PCOS women without NAFLD [2.92 (2.21-3.25) control women, 2.14(1.63-2.64) PCOS women without NAFLD and 3.96(3.28-4.67) PCOS women with NAFLD, P < 0.05].
Conclusions NAFLD is common in PCOS patients compared with healty women and was related to insulin resistance. Liver evaluation is proposed in PCOS patients.