Objectives Uric acid is associated with cardiovascular disease such as coronary artery disease and hypertension in adults. However, among the Chinese children and adolescents, whether the uric acid was associated with the high blood pressure remained unknown. Therefore, this present study examined the association between uric acid levels and high blood pressure in a multi-ethnic study of Chinese children and adolescents using data from Xinjiang Congenital Heart Disease Survey (XCHDS).
Methods The young participants aged 10 to 15 years from the XCHDS were enrolled in this study. 3 logistic regression models were conducted to investigate the relationship between the high blood pressure and uric acid levels. The concentrations of uric acid between participants with or without the high blood pressure were calculated and compared.
Results A total of 3778 participants were included in the present study. The percentages of the high blood pressure in the four different uric acid quartiles were 7.4%, 8.6%, 9.6% and 11.8% respectively. In model 1, 2 and 3 of the logistic regression, the participants in the third and fourth uric acid quartiles had significantly higher chance of suffering the high blood pressure when compared with the participants in the first uric acid quartile (OR = 1.601, 1.627, 1.613, P = 0.006, 0.011, 0.013 respectively between participants in the first quartile and the third quartile; OR = 1.982, 1.962, 1.829, P = 0.001, 0.002, 0.006 respectively between participants the first quartile and the fourth quartile). The concentrations of serum uric acid were 220.67 ± 72.00 μmol/L in participants with the high blood pressure and 204.07 ± 64.32 μmol/L in participants without the high blood pressure (P = 0.024).
Conclusions Among Chinese children and adolescents, increasing levels of serum uric acid are associated with high blood pressure.