Objectives To investigate the association between suppressor of cytokine signalling 3(SOCS3) genetic polymorphisms and insulin resistance (IR) in Xinjiang Uygur population.
Methods In this cross-sectional study on the metabolic diseases (e.g. obesity) among Uygur Chinese in Hetian, Xinjiang China,1292 Uygur individuals were enrolled. The sample size for IR subjects[homeostasismodel assessment for insulin resistance (HOMA-IR) 2.96] was 323, whereas that for non-IR controls was 969(HOMA-IR<2.96). Representative variations were selected according to gene database and genotyped using the TaqMan polymerase chain reaction method in 1292 Uygur individuals. A relatively isolated general population in a relatively homogeneous environment and a case-control study was conducted to test the association between the genetic variations of SOCS3 gene and insulin resistance.
Results All genotype distributions were tested for deviations from Hardy-Weinberg equnilibrium (P > 0.05). There was significant difference of genotype distribution of rs4969168 between insulin resistance and control groups in the male population (χ2 = 7.216, P = 0.027). Although the insulin resistance related quantitative phenotypes have no significantly difference in individuals with GG, AG and AA genotypes of rs4969168 in total, male and female population (P > 0.05), the mean of body mass index and the median of fasting insulin increased in individuals with GG, AG, AA genotypes of rs4969168 in male population. But not in total and female population. The logistic regression analysis showed that AG genotype of rs4969168 variation might be a protective factor for insulin resistance in male (OR = 0.564,95% confidence interval 0.344-0.925, P = 0.023).
Conclusions The present study suggests that the rs4969168 polymorphism in SOCS3 gene may be associated with insulin resistance in Xinjiang Uygur men.