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GW24-e3783 The role of CD46 in mouse cerebral ischaemia-reperfusion injury
  1. Yan MuYang1,
  2. Zhao Jun1,
  3. Zhang Chuanfu2,
  4. Song Hongbin2,
  5. Zhang Tingfen1
  1. 1The Institute of Geriatric Cardiology of Chinese PLA General Hospital
  2. 2Institute of Disease Control and Prevention, Academy of Military Medical Science

Abstract

Objectives To investigate dynamic changes of complement regulatory protein CD46 expression and discuss its possible mechanisms. During cerebral ischaemia-reperfusion injury.

Methods The middle cerebral artery occlusion (MACO) model was induced through filament method. Brain Pathological injury was recorded. Immunofluorescence and real time RT-PCR method were used to detect complement regulatory protein CD46 expression.

Results Brain pathological injury was the most serious at 24 h after reperfusion, The complement regulatory protein CD46 expression decreased gradually after local cerebral ischaemia-reperfusion injury, the lowest at 24 h after reperfusion, and returned to normal at 96 h after reperfusion.complement regulatory protein CD46 expression was negative correlated with brain pathological injury.

Conclusions The complement regulatory protein CD46 has a significant change after cerebral ischaemia-reperfusion, it was speculated that participate in the course of the injury after ischaemia-reperfusion, So inhibition of complement by complement regulatory protein CD46 is likely to be a new important method of treatment.

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