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GW24-e3067 Animal model for unloading the rat hearts of end-stage dilated cardiomyopathy
  1. Meng Zili1,
  2. Li Hongwei2,
  3. Li Qiang1
  1. 1Department of Cardiovascular Surgery, Hebei Chest Hospital, Shijiazhuang, Hebei Province 050041, China
  2. 2Department of Cardiovascular Surgery, The Second Affiliated Hospital of Zhengzhou University

Abstract

Objectives To create a model of minicking VAD by unloading rats with HF (heart failure) after dilated cardiomyopathy in rats.

Methods Heart failure (HF) was induced by the intraperitoneal administration of doxorubicin (total dose 15 mg/kg) in rat. Rats with HF after dilated cardiomyopathy were unloaded by heterotopic cardiac transplantation for 2 weeks.

Results The rate of heart failure after dilated cardiomyopathy successfully was 73.6%. The rate of the unloading the rats with HF after dilated cardiomyopathy successfully was 84.9%. Two weeks after transplantation, Langendorff perfusion demonstrated that both maximum dP/dt (2323.04 ± 143.50 vs. 2032.11 ± 101.1 mm Hg/s, P < 0.05) and minimum dP/dt (1337.92 ± 98.3 vs. 1012.22 ± 93.4mm Hg/s, P < 0.01) were improved in HF-unloaded hearts compared with HF hearts.

Conclusions We establish a model mimicking partially the Left Venticular assist Device (LVAD). The dilated cardiomyopathy cardiac function could be improved by unloading.

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