Objectives Epidemiologic studies have been performed to explore the relationship between MCP-1 polymorphism and ischaemic heart disease (IHD) and ischaemic stroke (IS). But, the results are not consistent. Because of the poor effect of single study, we performed a systematic review and meta-analysis
Methods A comprehensive search was carried out from PubMed, Foreign Medical Journal Service (FMJS), China National Knowledge Infrastructure (CNKI) and Wanfang Data. Odds ratios (OR) with 95% confidence interval (CI) were used to evaluate the strength of association between the MCP-1 A-2518G polymorphism (rs1024611) and IHD and IS susceptibility. The pooled OR were calculated by the allelic model (G versus A), additive model (GG versus AA), dominant model (GG + GA versus AA) and recessive model (GG versus AA + GA). The homogeneity among studies was checked using Cochrane Q statistic. The stability of results was checked by one-way sensitivity analysis. The publication bias between studies was examined by Begg’s funnel plots and Egger’s test.
Results 28 eligible case-control studies met all the criteria and were involved in the present meta-analysis, including a total of 8,901 cases and 12,623 controls. Overall, the MCP-1 A-2518G polymorphism was significantly associated with IHD susceptibility. The pooled OR was 1.269 (95% CI: 1.091-1.475, P = 0.002) in dominant model, 1.203 (95% CI: 1.074-1.346, P = 0.001) in allelic model, 1.252 (95% CI: 1.045-1.500, P = 0.015) in recessive model and 1.390 (95% CI: 1.103-1.752, P = 0.005) in additive model. At the same time, the MCP-1 A-2518G polymorphism was significantly associated with IS susceptibility. The pooled OR was 1.723 (95%CI: 1.120-2.649, P = 0.013) in dominant model, 1.394 (95% CI: 1.116-1.741, P = 0.003) in allelic model, 1.585 (95% CI: 1.303-1.928, P = 0.000) in recessive model, and 2.329 (95%CI: 1.759-3.082, P = 0.000) in additive model, respectively. No significant publication bias was found in the present meta-analysis.
Conclusions The results of the present meta-analysis suggest that MCP-1 gene A-2518G polymorphism may be associated with the susceptibility to IHD and IS. But, the positive result exists in relatively small sample size subgroup.