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GW24-e1010 The association between the MCP-1-2518 A/G polymorphism and ischaemic heart disease and ischaemic stroke: a meta-analysis of 28 research studies involving 21, 524 individuals
  1. Cai Gaojun
  1. Wujin Hospital, Affiliated to Jiangsu University

Abstract

Objectives Epidemiologic studies have been performed to explore the relationship between MCP-1 polymorphism and ischaemic heart disease (IHD) and ischaemic stroke (IS). But, the results are not consistent. Because of the poor effect of single study, we performed a systematic review and meta-analysis

Methods A comprehensive search was carried out from PubMed, Foreign Medical Journal Service (FMJS), China National Knowledge Infrastructure (CNKI) and Wanfang Data. Odds ratios (OR) with 95% confidence interval (CI) were used to evaluate the strength of association between the MCP-1 A-2518G polymorphism (rs1024611) and IHD and IS susceptibility. The pooled OR were calculated by the allelic model (G versus A), additive model (GG versus AA), dominant model (GG + GA versus AA) and recessive model (GG versus AA + GA). The homogeneity among studies was checked using Cochrane Q statistic. The stability of results was checked by one-way sensitivity analysis. The publication bias between studies was examined by Begg’s funnel plots and Egger’s test.

Results 28 eligible case-control studies met all the criteria and were involved in the present meta-analysis, including a total of 8,901 cases and 12,623 controls. Overall, the MCP-1 A-2518G polymorphism was significantly associated with IHD susceptibility. The pooled OR was 1.269 (95% CI: 1.091-1.475, P = 0.002) in dominant model, 1.203 (95% CI: 1.074-1.346, P = 0.001) in allelic model, 1.252 (95% CI: 1.045-1.500, P = 0.015) in recessive model and 1.390 (95% CI: 1.103-1.752, P = 0.005) in additive model. At the same time, the MCP-1 A-2518G polymorphism was significantly associated with IS susceptibility. The pooled OR was 1.723 (95%CI: 1.120-2.649, P = 0.013) in dominant model, 1.394 (95% CI: 1.116-1.741, P = 0.003) in allelic model, 1.585 (95% CI: 1.303-1.928, P = 0.000) in recessive model, and 2.329 (95%CI: 1.759-3.082, P = 0.000) in additive model, respectively. No significant publication bias was found in the present meta-analysis.

Conclusions The results of the present meta-analysis suggest that MCP-1 gene A-2518G polymorphism may be associated with the susceptibility to IHD and IS. But, the positive result exists in relatively small sample size subgroup.

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