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GW24-e2207 Association between--1562 C>T polymorphism in the promoter region of matrix metalloproteinase-9 (MMP-9) and coronary artery disease: A meta-analysis
  1. Guan Weiwei Chenken1,2,
  2. Hongmei Ren1,2,
  3. Lin Zhou1,2,
  4. Chunyu Zeng1,2
  1. 1Department of Cardiology, Daping Hospital, The Third Military Medical University,
  2. 2Chongqing Institute of Cardiology, Chongqing, PR China

Abstract

Objectives To determine the association between-1562 C>T polymorphism in the promoter region of matrix metalloproteinase-9 (MMP-9) and coronary artery disease (CAD) risk.

Methods This meta-analysis was on the basis of 26 studies including 12,776 cases and 6,371 controls. The was assessed by the Q-statistic test and the I2-statistic test. Sensitivity analysis was conducted by sequentially omitting any single study and recalculating the ORs and 95% CIs. Funnel plots and Egger’s test were performed to test the potential publication bias. All the data were analysed by using STATA version 12.0.

Results We found that-1562 C>T polymorphism did not contribute to susceptibility to CAD in the overall results (ORCC vs. TT= 0.99, 95% CI = 0.94-1.04, P heterogeneity= 1.000; ORCC + CT vs. TT = 0.99, 95% CI = 0.95-1.04, P heterogeneity= 1.000; ORCC vs. CT + TT= 0.96, 95% CI = 0.92-1.01, P heterogeneity= 0.992; ORallele C vs. allele T= 0.98, 95% CI = 0.95-1.01, P heterogeneity= 1.000; ORCT vs. TT= 0.98, 95% CI = 0.89-1.07, P heterogeneity = 1.000). But the stratified analysis by ethnicity and source of control indicated-1562 C>T polymorphism may be a risk factor for the CAD risk in Asians and hospital populations.

Conclusions Our meta-analysis supported the fact that-1562 C>T polymorphism was not associated with the susceptibility to CAD. Further larger studies are required to confirm our findings.

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