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One Day Kinetics of Myocardial Engraftment After Intracoronary Injection of Bone Marrow Mononuclear Cells in Patients with Acute and Chronic Myocardial Infarction.
  1. Martin Penicka (penicka{at}fnkv.cz)
  1. 3rd Medical School Charles University and University Hospital Kralovske Vinohrady, Czech Republic
    1. Otto Lang
    1. 3rd Medical School Charles University and University Hospital Kralovske Vinohrady, Czech Republic
      1. Petr Widimsky
      1. 3rd Medical School Charles University and University Hospital Kralovske Vinohrady, Czech Republic
        1. Petr Kobylka
        1. Institute of Hematology and Blood Transfusion, Czech Republic
          1. Tomas Kozak
          1. 3rd Medical School Charles University and University Hospital Kralovske Vinohrady, Czech Republic
            1. Tomas Vanek
            1. 3rd Medical School Charles University and University Hospital Kralovske Vinohrady, Czech Republic
              1. Jaroslav Dvorak
              1. 3rd Medical School Charles University and University Hospital Kralovske Vinohrady, Czech Republic
                1. Jaroslav Tintera
                1. Institute of clinical and experimental medicine, Czech Republic
                  1. Jozef Bartunek
                  1. Cardiovascular Center OLV Hospital, Belgium

                    Abstract

                    Objective To investigate the kinetics of myocardial engraftment of bone marrow-derived mononuclear cells (BMNCs) after intracoronary injection using 99mTc-d,l-hexamethylpropylene amine oxime (99mTc-HMPAO) nuclear imaging in patients with acute and chronic anterior myocardial infarction.

                    Design Nuclear imaging-derived tracking of BMNCs at 2 and 20 hours after injections in the left anterior descending coronary artery.

                    Setting Academical cardiocenter.

                    Patients Five patients with acute (age 58 ± 11yrs; ejection fraction range 33% to 45%) and 5 patients with chronic (age 50 ± 6yrs; ejection fraction range 28% to 34%) anterior myocardial infarction.

                    Interventions A total of 24.2x108 to 57.0x108 BMNCs (20 % labeled with 700-1000 MBq 99mTc-HMPAO) were injected in the left anterior descending coronary artery.

                    Results At 2 hours after BMNCs injections, myocardial activity was observed in all patients with acute (range 1.31% to 5.10%) and in all but one patient with chronic infarction (range 1.10% to 3.0%). At 20 hours, myocardial engraftment was noted only in 3 patients with acute myocardial infarction, while no activity remained in the myocardium in any patient with chronic infarction.

                    Conclusions Engraftment of BMNCs displays dynamic changes within first 20 hours after intracoronary injections. Persistent myocardial engraftment was noted only in subset of patients with acute myocardial infarction.

                    • bone marrow cells
                    • imaging
                    • myocardial infarction
                    • nuclear medicine

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