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Neopterin is associated with plaque inflammation and destabilization in human coronary atherosclerotic lesions
  1. Taichi Adachi
  1. Osaka City General Hospital, Japan
    1. Takahiko Naruko (tmnaruko{at}msic.med.osaka-cu.ac.jp)
    1. Osaka City General Hospital, Japan
      1. Akira Itoh
      1. Osaka City General Hospital, Japan
        1. Ryushi Komatsu
        1. Osaka City General Hospital, Japan
          1. Yukio Abe
          1. Osaka City General Hospital, Japan
            1. Nobuyuki Shirai
            1. Osaka City University Graduate School of Medicine, Japan
              1. Hajime Yamashita
              1. Osaka City University Graduate School of Medicine, Japan
                1. Shoichi Ehara
                1. Osaka City University Graduate School of Medicine, Japan
                  1. Masashi Nakagawa
                  1. Osaka City University Graduate School of Medicine, Japan
                    1. Chizuko Kitabayashi
                    1. Osaka City University Graduate School of Medicine, Japan
                      1. Yoshihiro Ikura
                      1. Osaka City University Graduate School of Medicine, Japan
                        1. Masahiko Ohsawa
                        1. Osaka City University Graduate School of Medicine, Japan
                          1. Minoru Yoshiyama
                          1. Osaka City University Graduate School of Medicine, Japan
                            1. Kazuo Haze
                            1. Osaka City General Hospital, Japan
                              1. Makiko Ueda
                              1. Osaka City University Graduate School of Medicine, Japan

                                Abstract

                                Objective Previous studies have shown that recent activation of the imflammatory response in coronary atherosclerotic lesions contributes to rapid progressive plaque destabilization. Neopterin, a by-product of the guanosine triphosphate pathway, is produced by activated macrophages and serves as an activation marker for monocytes/macrophages. To elucidate the role of neopterin in coronary plaque destabilization, we immunohistochemically studied the presence of neopterin in coronary atherectomy specimens obtained from patients with stable angina pectoris (SAP) and unstable angina pectoris (UAP).

                                Design and patients All patients underwent atherectomy of the primary atherosclerotic lesions responsible for SAP (n=25) and UAP (n=25). Frozen samples were studied with antibodies against smooth muscle cells, macrophages, T cells, neutrophils, and neopterin.

                                Results In 22 of the 25 patients with UAP, abundant neopterin-positive macrophages were found at the sites of coronary culprit lesions. However, in 25 lesions from SAP patients, only 11 lesions showed neopterin positivity. Quantitatively, the neopterin-positive macrophage score was significantly higher (P<0.0001) in patients with UAP than in patients with SAP. Moreover, the neopterin-positive macrophage score showed a significant positive correlation with the number of neutrophils or T cells, respectively (neutrophils, r = 0.55, P<0.0001; T cells, r = 0.70, P<0.0001).

                                Conclusions Neopterin can be considered as one of the significant factors in the process of plaque inflammation and destabilization in human coronary atherosclerotic lesions. However, it∝fs exact role in the process needs to be further investigated.

                                • angina
                                • atherosclerosis
                                • inflammation
                                • neopterin

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