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Arachidonic Acid and Docosahexaenoic Acid Supplementation Increases Coronary Flow Velocity Reserve in Japanese Elderly Individuals
  1. Hiroki Oe (h-oe{at}msic.med.osaka-cu.ac.jp)
  1. Osaka City University, Japan
    1. Takeshi Hozumi (take-hzm{at}wb3.so-net.ne.jp)
    1. Osaka City University, Japan
      1. Eriko Murata
      1. Osaka City University, Japan
        1. Hitoe Matsuura
        1. Osaka City University, Japan
          1. Kazuaki Negishi
          1. Osaka City University, Japan
            1. Yoshiki Matsumura
            1. Osaka City University, Japan
              1. Shinichi Iwata
              1. Osaka City University, Japan
                1. Keitaro Ogawa
                1. Osaka City University, Japan
                  1. Kenichi Sugioka
                  1. Osaka City University, Japan
                    1. Yasuhiko Takemoto
                    1. Osaka City University, Japan
                      1. Kenei Shimada
                      1. Osaka Ekisaikai Hospital, Japan
                        1. Minoru Yoshiyama
                        1. Osaka City University, Japan
                          1. Yoshiyuki Ishikura
                          1. Institute for Health Care Science, SUNTORY Ltd, Japan
                            1. Yoshinobu Kiso
                            1. Institute for Health Care Science, SUNTORY Ltd, Japan
                              1. Junichi Yoshikawa
                              1. Osaka Ekisaikai Hospital, Japan

                                Abstract

                                Background Arachidonic acid (ARA) and docosahexaenoic acid (DHA) are important components of phospholipids and cell membranes. However, there has been no clinical report on the direct effects of ARA and DHA on coronary circulation.

                                Objective To evaluate the effects of ARA and DHA on coronary circulation using measurement of coronary flow velocity reserve (CFVR) by transthoracic Doppler echocardiography (TTDE).

                                Methods This was a double-blind, placebo-matched study of 28 Japanese elderly individuals (19 men, mean 65 years) conducted to compare the effects of polyunsaturated fatty acid (PUFA) (ARA: 240mg/day, DHA: 240mg/day) and placebo on CFVR. Coronary flow velocity (CFV) of the left anterior descending coronary artery (LAD) was measured at rest and during hyperemia by TTDE to determine CFVR.

                                Results There were no significant differences in CFV at rest or during hyperemia in CFVR at baseline in the 2 groups (PUFA vs placebo: 17 ± 7 vs 16 ± 6, 62 ± 20 vs 59 ± 12, and 3.85 ± 1.04 vs 3.98 ± 0.83 cm/s, respectively). After 3-month supplementation, CFV during hyperemia was significantly higher in the PUFA than in the placebo group (73 ± 19 vs 64 ± 12 cm/s, p<0.01) although no significant difference was found between the two groups in CFV at rest (17 ± 7 vs 16 ± 4 cm/s). Thus, CFVR significantly increased after PUFA consumption (3.85 ± 1.04 vs. 4.46 ± 0.95, p=0.0023).

                                Conclusion Three-month supplementation of PUFA increased CFVR in Japanese elderly individuals, which suggests the beneficial effects of PUFA on the coronary microcirculation.

                                • arachidonic acid (ARA)
                                • coronary flow reserve (CFR)
                                • docosahexaenoic acid (DHA)
                                • polyunsaturated fatty acid (PUFA)
                                • transthoracic Doppler echocardiography (TTDE)

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