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Does optical coherence tomography identify arterial healing after stenting? An in vivo comparison with histology, on a rabbit carotid model
  1. Francesco Prati (fprati{at}hsangiovanni.roma.it)
  1. Interventional Cardiology, San Giovanni-Addolorata Hospital - Rome, Italy
    1. Marco Zimarino (m.zimarino{at}unich.it)
    1. Institute of Cardiology and Center of Excellence on Aging - "G. d'Annunzio" University of Chieti, Italy
      1. Eugenio Stabile
      1. Cath Lab, Casa di Cura "Montevergine", Mercogliano - Avellino, Italy
        1. Giuseppe Pizzicannella
        1. Institute of Cardiology and Center of Excellence on Aging - "G. d'Annunzio" University of Chieti, Italy
          1. Tamer Fouad
          1. Interventional Cardiology, San Giovanni-Addolorata Hospital - Rome, Italy
            1. Roberto Rabozzi
            1. Institute of Cardiology and Center of Excellence on Aging - "G. d'Annunzio" University of Chieti, Italy
              1. Arnaldo Filippini
              1. Institute of Cardiology and Center of Excellence on Aging - "G. d'Annunzio" University of Chieti, Italy
                1. Jacopo Pizzicannella
                1. Institute of Cardiology and Center of Excellence on Aging - "G. d'Annunzio" University of Chieti, Italy
                  1. Maria Cera
                  1. Interventional Cardiology, San Giovanni-Addolorata Hospital - Rome, Italy
                    1. Raffaele De Caterina
                    1. Institute of Cardiology and Center of Excellence on Aging - "G. d'Annunzio" University of Chieti, Italy

                      Abstract

                      Objective To verify whether optical coherence tomography (OCT) can accurately monitor the occurrence of arterial healing after stenting.

                      Setting Delayed stent endothelization may predispose to stent thrombosis. OCT is an high-resolution intravascular imaging technique that accurately identifies stent struts and arterial tissues.

                      Design and interventions Eight New Zealand white rabbits underwent the implantation of single bare metal stents (diameter 2-2.5 mm, length 8-13 mm) in the common carotid artery through the external carotid artery. After a median of 11 days (range 2-28), the stented arteries were visualised by OCT, with images acquired at a pull-back speed of 0.5 mm/sec. The rabbits were then euthanized, vessels were formalin fixed and finally processed for histopathology.

                      Results We analyzed 32 cross-sections from 8 stented carotid arteries, for a total of 384 stent struts. OCT detected all of the stent struts in 30/32 cross-sections (93.7%), and correctly identified the presence/absence of tissue for every strut. Histological and OCT measurements of mean neointima thickness (0.135±0.079 mm and 0.145±0.085 mm, respectively, p=NS) were similar and closely related (R=0.85, P<0.001). Neointima area progressively increased with longer time intervals from stent deployment to sacrifice; histological and OCT measurements were similar for each time interval. The intra- and inter-observer reproducibility of OCT neointima measurements were excellent (R2= 0.90 and 0.88, respectively).

                      Conclusions OCT is a promising means for monitoring stent strut coverage and vessel wall healing in vivo, the relevance of which will become even more significant with the increasing use of drug eluting stents.

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