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Workload at the Heart Rate of 100 Beats/min and Mortality in Middle-Aged Men with Known or Suspected Coronary Heart Disease
  1. Kai P Savonen (savonen{at}hytti.uku.fi)
  1. Kuopio Research Institute of Exercise Medicine, Finland
    1. Timo A Lakka (timo.lakka{at}uku.fi)
    1. Kuopio Research Institute of Exercise Medicine, Finland
      1. Jari A Laukkanen (jaalaukk{at}messi.uku.fi)
      1. Kuopio Research Institute of Exercise Medicine, Finland
        1. Tuomas H Rauramaa (tuomas.rauramaa{at}fimnet.fi)
        1. Kuopio Research Institute of Exercise Medicine, Finland
          1. Jukka T Salonen (jukka.salonen{at}uku.fi)
          1. School of Public Health and Clinical Nutrition, University of Kuopio, Finland
            1. Rainer Rauramaa (rainer.rauramaa{at}messi.uku.fi)
            1. Kuopio Research Institute of Exercise Medicine, Finland

              Abstract

              Objective To investigate whether a workload which an individual is able to perform at the heart rate (HR) of 100 beats/min (WL100) independently predicts mortality in middle-aged men with known or suspected coronary heart disease (CHD).

              Design Prospective population-based study based on 365 middle-aged men with known or suspected CHD at baseline.

              Results During an average follow-up of 11.1 years, there were 75 deaths (20.5%). In Cox multivariable models mortality increased by 72% (95% CI 32%-122%, p<0.001) with 1 SD (34 Watts) decrement in WL100 after adjustment for age, examination year, alcohol consumption, body mass index, cigarette smoking, cardiac insufficiency, history of myocardial infarction, diabetes, myocardial ischemia during exercise test, serum low-density lipoprotein and high-density lipoprotein cholesterol, systolic and diastolic blood pressure at rest, testing protocol, and use of HR-lowering medication. The risk of death was 2.4 (95% CI 1.5-4.0, p<0.001) times higher in 130 men with WL100 <55 W than in 235 men with WL100 iÝ55 W. In men using and not using HR-lowering medication the risk of death increased 72% (95% CI 14%-163%, p=0.01), and 54% (95% CI 14%-108%, p=0.005) with 1 SD decrement in WL100, respectively. WL100 improved the predictive power of the adjusted Cox models including other HR and exercise test variables.

              Conclusions WL100 predicts mortality in men with known or suspected CHD. The association of WL100 with mortality was not explained by other well-established HR and exercise test variables. WL100 is derived from a submaximal test which avoids the cardiovascular risks associated with a high-intensity exertion.

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