Article Text

other Versions

PDF
Effects of Stem Cell Therapy with G-CSF on Coronary Artery after Drug-Eluting Stent Implantation in Patients with Acute Myocardial Infarction
  1. Hyun-Jae Kang (nowkang{at}snu.ac.kr)
  1. Seoul National University Hospital, Korea, Republic of
    1. Yong-Seok Kim
    1. DongGuk University International Hospital, Korea, Republic of
      1. Bon-Kwon Koo
      1. Seoul National University Hospital, Korea, Republic of
        1. Kyung Woo Park
        1. Seoul National University Hospital, Korea, Republic of
          1. Hae-Young Lee
          1. Seoul National University Hospital, Korea, Republic of
            1. Dae-Won Sohn
            1. Seoul National University Hospital, Korea, Republic of
              1. Byung-Hee Oh
              1. Seoul National University Hospital, Korea, Republic of
                1. Young-Bae Park (parkyb{at}snu.ac.kr)
                1. Seoul National University Hospital, Korea, Republic of
                  1. Hyo-Soo Kim (hyosoo{at}snu.ac.kr)
                  1. Seoul National University Hospital, Korea, Republic of

                    Abstract

                    Objective We evaluated the effects of stem cell therapy on the coronary vasculature in patients with acute myocardial infarction who underwent peripheral blood stem cells (PBSCs) therapy in MAGIC Cell-3-DES study.

                    Methods Among 50 patients with acute myocardial infarction who received either sirolimus-eluting stent or paclitaxel-eluting stent implantation for the culprit lesion, we analyzed intravascular ultrasound in 36 patients (cell infusion: n=19 and control: n=17). In the cell infusion group, PBSCs mobilized by granulocyte-colony stimulating factor were delivered via intracoronary infusion into infarcted myocardium. We evaluated proximal and distal reference segments, and stented segments with intravascular ultrasound at immediate post-intervention and 6 month follow-up, respectively.

                    Results In the proximal and distal reference segments, the serial changes of lumen area, vessel area, and plaque plus media area were not significantly different between the cell infusion and the control groups. Within stented segments, mean neointimal area was similar between the two groups (cell infusion: 0.2 i3/4 0.5mm2 vs. control: 0.3 i3/4 0.4mm2, p>0.05). However, there was a significant increase in mean peri-stent area of stented segment in the cell infusion group compared to the control group (0.7 i3/4 1.4mm2 vs. -0.1 i3/4 1.2mm2, p<0.05). This difference mainly came from paclitaxel-eluting stent implanted patients.

                    Conclusion Intracoronary infusion of the mobilized PBSCs with G-CSF does not aggravate de novo atherosclerotic lesion and neointimal hyperplasia with DES implantation. However, it may induce peri-stent tissue growth at stented segment especially in patients receiving PES. Its clinical significance needs to be evaluated with long term follow up.

                    Statistics from Altmetric.com

                    Request permissions

                    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.