Article Text

other Versions

PDF
Improvement of Left Ventricular Myocardial Short-axis, but not Long-axis Function or Torsion after Cardiac Resynchronization Therapy-An Assessment by Two-Dimensional Speckle Tracking
  1. Qing Zhang
  1. The Chinese University of Hong Kong, Hong Kong
    1. Jeffrey WH Fung
    1. The Chinese University of Hong Kong, Hong Kong
      1. Gabriel WK Yip
      1. The Chinese University of Hong Kong, Hong Kong
        1. Joseph YS Chan
        1. The Chinese University of Hong Kong, Hong Kong
          1. Alex PW Lee
          1. The Chinese University of Hong Kong, Hong Kong
            1. Yat-yin Lam
            1. The Chinese University of Hong Kong, Hong Kong
              1. Li-wen Wu
              1. The Chinese University of Hong Kong, Hong Kong
                1. Eugene B Wu
                1. The Chinese University of Hong Kong, Hong Kong
                  1. Cheuk-man Yu (cmyu{at}cuhk.edu.hk)
                  1. The Chinese University of Hong Kong, Hong Kong

                    Abstract

                    Aims This study was to evaluate whether short-axis function play a role in determining LV geometric and functional improvement after cardiac resynchronization therapy (CRT).

                    Methods and Results 39 patients who received CRT were enrolled. 2D speckle tracking echocardiography was performed at baseline and 3 months after CRT to assess mean systolic circumferential (∊-circum), radial (∊-radial), longitudinal (∊-long) strain and torsion. There were 21 responders of reverse remodeling who had higher baseline mean ∊circum than non-responders (p<0.05), while both mean ∊-circum (p<0.005) and mean ∊-radial (p<0.05) were only improved in responders. Improvement of mean ∊-circum correlated with increase in ejection fraction (r=0.57, p<0.001) and decrease in mid-cavity width (r=-0.52, p=0.001). A baseline mean ∊-circum of ≥6.5% predicted a gain in ejection fraction ≥5%, with a sensitivity of 73% and a specificity of 71%. The baseline ∊-long was not different between the 2 groups, and remained unchanged after CRT. The torsion did not improve in responders, but was worsened in non-responders (p<0.05).

                    Conclusions The improvement of LV short-axis function but not long-axis function or torsion contributes to the changes in LV global function and geometry at 3-month follow up. A relatively preserved mean ∊-circum of ≥6.5% might be useful to predict favorable responses after CRT.

                    • 2-dimensional speckle tracking
                    • Cardiac Resynchronization Therapy
                    • Echocardiography
                    • Heart Failure
                    • Myocardial Function

                    Statistics from Altmetric.com

                    Request permissions

                    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.