Aims This study was to evaluate whether short-axis function play a role in determining LV geometric and functional improvement after cardiac resynchronization therapy (CRT).
Methods and Results 39 patients who received CRT were enrolled. 2D speckle tracking echocardiography was performed at baseline and 3 months after CRT to assess mean systolic circumferential (∊-circum), radial (∊-radial), longitudinal (∊-long) strain and torsion. There were 21 responders of reverse remodeling who had higher baseline mean ∊circum than non-responders (p<0.05), while both mean ∊-circum (p<0.005) and mean ∊-radial (p<0.05) were only improved in responders. Improvement of mean ∊-circum correlated with increase in ejection fraction (r=0.57, p<0.001) and decrease in mid-cavity width (r=-0.52, p=0.001). A baseline mean ∊-circum of ≥6.5% predicted a gain in ejection fraction ≥5%, with a sensitivity of 73% and a specificity of 71%. The baseline ∊-long was not different between the 2 groups, and remained unchanged after CRT. The torsion did not improve in responders, but was worsened in non-responders (p<0.05).
Conclusions The improvement of LV short-axis function but not long-axis function or torsion contributes to the changes in LV global function and geometry at 3-month follow up. A relatively preserved mean ∊-circum of ≥6.5% might be useful to predict favorable responses after CRT.
- 2-dimensional speckle tracking
- Cardiac Resynchronization Therapy
- Heart Failure
- Myocardial Function
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