At the end of 2007, Science recognized human genetic variation as the “breakthrough of the year” (1). Beginning in April last year and extending through the current year, on nearly a weekly basis, major advances have been made to unravel common DNA sequence variants that are incontrovertibly associated with common diseases. The number of diseases that have been reported on is now greater than 50, and many cardiovascular conditions are included in this avalanche of discoveries. There probably has been more progress in understanding the genomics of disease in the past year than for several previous decades in aggregate.
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