Article Text

other Versions

PDF
Serum Intact Parathyroid Hormone levels predict hospitalization for heart failure
  1. Tadafumi Sugimoto (t_sugimoto_japan{at}hotmail.com)
  1. Matsusaka Chuo General Hospital, Japan
    1. Takashi Tanigawa
    1. Matsusaka Chuo General Hospital, Japan
      1. Katsuya Onishi (katsu{at}clin.medic.mie-u.ac.jp)
      1. Mie University School of Medicine, Japan
        1. Naoki Fujimoto
        1. Mie University School of Medicine, Japan
          1. Akimasa Matsuda
          1. Matsusaka Chuo General Hospital, Japan
            1. Shiro Nakamori
            1. Matsusaka Chuo General Hospital, Japan
              1. Koji Matsuoka
              1. Matsusaka Chuo General Hospital, Japan
                1. Tomoaki Nakamura
                1. Matsusaka Chuo General Hospital, Japan
                  1. Takakazu Koji
                  1. Matsusaka Chuo General Hospital, Japan
                    1. Masaaki Ito (mitoka{at}clin.medic.mie-u.ac.jp)
                    1. Mie University School of Medicine, Japan

                      Abstract

                      Objective: To assess whether circulating levels of intact parathyroid hormone (intact PTH) in outpatients predict hospitalization for heart failure (HF).

                      Methods: Eighty-eight consecutive outpatients with HF were enrolled in the present study. The independent association between intact PTH and hospitalization for HF was assessed using Cox regression analysis.

                      Results: Serum intact PTH levels significantly increased as New York Heart Association (NYHA) classes increased [I: 40 (21), II: 55 (24), III: 76 (46), IV: 131 (45) pg/ml, mean (SD)]. The receiver operating characteristic (ROC) curves demonstrated intact PTH levels ≥ 47 pg/ml to be the optimal cut-off points for hospitalization for HF with sensitivity 87 %, specificity 71 %, and area under the ROC curve: 0.82 (95% CI: 0.72 to 0.91). After adjustment for variables accepted to be predictors for hospitalization due to HF (age, gender, hypertension, diabetes mellitus, atrial fibrillation, ischemic heart disease, left ventricular ejection fraction, B-type natriuretic peptide, estimated glomerular filtration rate and cardiac medication), intact PTH levels ≥ 47 pg/ml were associated with a hazard ratio of 7.13 for hospitalization for HF (95% CI: 1.79 to 28.4).

                      Conclusion: Serum intact PTH levels obtained in outpatients with HF was shown to be an independent predictor of hospitalization for HF.

                      Statistics from Altmetric.com

                      Request permissions

                      If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.