Article Text

other Versions

PDF
Left ventricular function and energy metabolism in middle-age men undergoing long lasting sustained aerobic oxidative training
  1. Gianluca Perseghin (perseghin.gianluca{at}hsr.it)
  1. Università degli Studi di Milano & Istituto Scientifico H San Raffaele, Italy
    1. Francesco De Cobelli
    1. Diagnostic Radiology - Istituto Scientifico H San Raffaele, Italy
      1. Antonio Esposito
      1. Diagnostic Radiology - Istituto Scientifico H San Raffaele, Italy
        1. Elena Belloni
        1. Diagnostic Radiology - Istituto Scientifico H San Raffaele, Italy
          1. Guido Lattuada
          1. Internal Medicine - Istituto Scientifico H San Raffaele, Italy
            1. Tamara Canu
            1. Diagnostic Radiology - Istituto Scientifico H San Raffaele, Italy
              1. Pietro Luigi Invernizzi
              1. Faculty of Exercise Sciences - Università degli Studi di Milano, Italy
                1. Francesca Ragogna
                1. Internal Medicine - Istituto Scientifico H San Raffaele, Italy
                  1. Antonio La Torre
                  1. Faculty of Exercise Sciences - Università degli Studi di Milano, Italy
                    1. Paola Scifo
                    1. Nuclear Medicine - Istituto Scientifico H San Raffaele, Italy
                      1. Giampietro Alberti
                      1. Faculty of Exercise Sciences - Università degli Studi di Milano, Italy
                        1. Alessandro Del Maschio
                        1. Diagnostic Radiology and Università Vita e Salute San Raffaele, Italy
                          1. Livio Luzi
                          1. Università degli Studi di Milano & Istituto Scientifico H San Raffaele, Italy

                            Abstract

                            Objective: Ageing of the human heart is characterized by morphological, functional and metabolic changes. Short-term interventions and cross sectional studies in older individuals questioned the possibility that physical exercise may revert these alterations. In this study we aimed to assess whether in middle-aged men involved in regular and long lasting physical activity these alterations were attenuated.

                            Design: Left ventricular (LV) MRI and 3D-ISIS 31P-MRS were performed using a 1.5T scanner in 20 healthy, young and 25 healthy middle-aged non-obese men with a sedentary life-style (11 young and 14 middle-age) or undergoing regular aerobic oxidative training (9 young and 11 middle-age). Insulin sensitivity was estimated by the HOMA-2 model.

                            Results: Sedentary young and middle-aged men were not different with respect to LV morphological parameters and systolic function. The PCr/ATP ratio (marker of high energy phosphates metabolism) and the LV E/A peak flow ratio were lower in sedentary middle-aged than physically active subjects. Parameters of LV systolic function and the PCr/ATP ratio were not different in the middle-aged than in the young trained men; the E/A peak flow ratio was higher in the middle-aged trained men than in the middle-aged sedentary men. Within the entire population, the PCr/ATP ratio and the E/A peak flow ratio were associated with insulin sensitivity.

                            Conclusions: Trained middle-aged subjects showed a better pattern of LV energy metabolism and of diastolic function than the sedentary counterparts. At this age the exercise-related cardiac benefits were detectable when physical exercise was performed regularly and for a long period of time.

                            Statistics from Altmetric.com

                            Request permissions

                            If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.