From what state are patients suffering now, and how will this change in the future? What events might punctuate this suffering, and at what rate will they accrue? What biological, behavioural and psychosocial traits lead people to these different states? These fundamental questions of prognosis research are as obvious as they are incompletely addressed. Enquiry into the future progression of people with existing disease is, or should be, a cornerstone of clinical practice, and translational medicine, and while we do know much about death after myocardial infarction, we know much less about prognosis in relation to other startpoints and other endpoints.
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