Article Text

other Versions

PDF
Diabetes and prognosis- Are systolic and diastolic heart failure different?
  1. Masoor Kamalesh (mkamales{at}iupui.edu)
  1. Indiana University, United States

    Abstract

    Multiple studies across countries have now shown that the long term prognosis of diastolic heart failure is not very different from that of systolic heart failure (1-3). If that is the case then why bother differentiating the two types of heart failure? The answer is because the treatment options differ greatly between the two conditions. While therapy (drug and device) is well characterized for systolic dysfunction (4), there are precious little data and options available for treating diastolic dysfunction (4). While ejection fractions and left ventricular cavity size differ between the two forms of heart failure, signs and symptoms and neurohumoral abnormalities are very similar between the two. These have been elegantly summarized recently by Chatterjee and Massie (5) (See Table). It has even been proposed that these two forms of heart failure may be different phenotypes of the same pathophysiologic basis (6). The stimuli responsible for these phenotypic differences is largely unknown (5,6,7).

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.