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Emergence of the Concept of Platelet Reactivity Monitoring of Response to Thienopyridines
  1. Laurent Bonello
  1. Washington Hospital Center, United States
    1. Axel De Labriolle
    1. Washington Hospital Center, United States
      1. Mickey Scheinowitz
      1. Washington Hospital Center, United States
        1. Gilles Lemesle
        1. Washington Hospital Center, United States
          1. Probal Roy
          1. Washington Hospital Center, United States
            1. Daniel H Steinberg
            1. Washington Hospital Center, United States
              1. Tina L Pinto Slottow
              1. Washington Hospital Center, United States
                1. Rajbabu Pakala
                1. Washington Hospital Center, United States
                  1. Augusto D Pichard
                  1. Washington Hospital Center, United States
                    1. Paul Barragan
                    1. Clinique les fleurs, France
                      1. Laurence Camoin-Jau
                      1. Hopital de la Conception, France
                        1. Françoise Dignat-George
                        1. Hopital de la Conception, France
                          1. Franck Paganelli
                          1. Hopital Universitaire Nord de Marseille, France
                            1. Ron Waksman (ron.waksman{at}medstar.net)
                            1. Washington Hospital Center, United States

                              Abstract

                              Clinical trials have demonstrated the beneficial impact of clopidogrel in preventing major adverse cardiovascular events (MACE), particularly in patients undergoing percutaneous coronary intervention (PCI). The concept of biological clopidogrel resistance emerged with the finding of persistent platelet activation despite clopidogrel therapy in some patients. Further, a link between biological clopidogrel resistance and thrombotic recurrence following PCI was observed and a threshold of platelet reactivity (PR) for thrombotic events was suggested. Consistently, in recent trials, enhanced PR inhibition translated into a reduction in the rate of MACE post-PCI. This review aims to present the emergence of the concept of PR monitoring in patients undergoing PCI following recent advances in this field.

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