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Prophylactic Cavotricuspid Isthmus Block during Atrial Fibrillation Ablation in Patients without Atrial flutter: a Randomized Controlled Trial
  1. Jacob Pontoppidan (pontoppidan{at}dadlnet.dk)
  1. Aarhus University Hospital Skejby, Denmark
    1. Jens Cosedis Nielsen (cosedis{at}dadlnet.dk)
    1. Aarhus University Hospital Skejby, Denmark
      1. Steen Hvitfeldt Poulsen (steen.hvitfeldt{at}dadlnet.dk)
      1. Aarhus University Hospital Skejby, Denmark
        1. Henrik Kjaerulf Jensen (hkjensen{at}dadlnet.dk)
        1. Aarhus University Hospital Skejby, Denmark
          1. Hakan Walfridsson (hakan.walfridsson{at}lio.se)
          1. Heart Center Varde, Denmark
            1. Anders Kirstein Pedersen (akp{at}ki.au.dk)
            1. Heart Center Varde, Denmark
              1. Peter Steen Hansen (pshansen{at}dadlnet.dk)
              1. Heart Center Varde, Denmark

                Abstract

                Objectives: This randomized trial evaluated if patients with atrial fibrillation (AF) and no history of atrial flutter (AFL) had any benefit of prophylactic cavotricuspid isthmus block (CTIB) in addition to circumferential pulmonary vein ablation (CPVA).

                Methods: We randomized 149 patients with AF (54% paroxysmal) to CPVA and CTIB (group CTIB+, n=73) or CPVA alone (group CTIB-, n=76). Patients were followed for 12 months with repetitive 7-days Holter monitoring after 3, 6, and 12 months.

                Results: Six patients (4%) had cardiac tamponade, and one patient had a stroke. We found no difference in the cumulative AFL-free rate between the two treatment groups (CTIB+: 88% versus CTIB-: 84%, Hazard Ratio (HR) 0.80, 95% CI (0.34-1.90), p=0.61). There was no difference in the cumulative AF-free rate between the groups (CTIB+: 34% versus CTIB-: 32%, HR 0.93, 95% CI (0.63-1.38), p=0.71). Overall, 33% of the patients were free of AF after a single procedure. Including additional CPVA procedures, a complete or partial beneficial effect was noted in 62% of the patients at 12 months. At 12 months follow-up, 24 (50%) patients with documented AF or AFL in the Holter recordings were asymptomatic.

                Conclusions: We could not demonstrate any beneficial effect of CTIB in addition to CPVA with regard to AFL or AF recurrences during follow-up. Repetitive long-term Holter monitoring demonstrated a 33% rate of freedom from AF during one-year follow-up. Including additional CPVA procedures, a clinical effect was noted in 62% of the patients at 12 months. Patients with AF or AFL recurrences were often asymptomatic.

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