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Strain rate evaluation of phasic atrial function in hypertension
  1. Suzanne Eshoo (suz2153{at}yahoo.com.au)
  1. University of Sydney, Westmead Hospital, Australia
    1. Anita C Boyd
    1. Westmead Hospital, Australia
      1. David L Ross
      1. University of Sydney, Westmead Hospital, Australia
        1. Thomas H Marwick
        1. University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
          1. Liza Thomas
          1. University of NSW, Liverpool Hospital, Australia

            Abstract

            Objectives: The objective of this study is to examine the feasibility of using strain (SI) and strain rate (SR) to evaluate phasic atrial function in patients with mild HT.

            Background: Strain and strain rate measure regional myocardial deformation and may be a novel technique to assess phasic atrial function.

            Design: The study population consisted of 54 patients with mild essential HT (29 females) and 80 age-matched normal controls (47 females). Standard two-dimensional and Doppler echocardiography was performed as well as Doppler tissue imaging. The following left atrial (LA) volumes were measured: 1) maximal LA volume or Volmax, 2) minimal LA volume or Volmin and 3) just prior to the ‘p’ wave on ECG (Volp). Phasic LA volumes were also calculated. Systolic (S-Sr), early diastolic (E-Sr), late diastolic (A-Sr) strain rate and SI were measured.

            Results: Despite no differences in indexed maximal LA volume with only mild increases in LV mass in the HT cohort compared to normals (86 ± 18 g/m2 vs. 67 ± 14 g/m2; p = 0.001), E-Sr was significantly lower in the HT cohort. There was a corresponding reduction in indexed conduit volume in the HT cohort vs. normals (10.5 ± 7.5 mL/m2 vs. 13.8 ± 6.1 mL/m2; p = 0.006). Global E-Sr showed modest negative correlations with LA Volmax and LAEF. No significant difference was present in S-Sr, A-Sr or global atrial strain between the normal and HT cohorts.

            Conclusion: We have demonstrated that mild HT results in a reduction in LA conduit volume although maximal LA volume is unchanged. This is reflected by a reduction in E-Sr with preserved S-Sr and A-Sr.

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