Coronary heart disease mortality has been falling steadily over the past 4-5 decades. In parallel, increasing numbers of people are surviving myocardial infarction (MI) and many face the challenges of a life with heart failure. Indeed, those suffering substantial myocardial injury often remain symptomatically limited even with aggressive modern management including revascularisation, an optimal medication regimen and, where appropriate, resynchronisation therapy. Immediate reperfusion remains the best way to minimise left ventricular injury and subsequent dysfunction however, despite streamlined systems of care and high profile public awareness campaigns all too many MIs present late or the diagnosis is missed. Thus, development and refinement of novel methodology for the repair of damaged cardiac tissue remains a major priority.
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