Article Text

other Versions

PDF
Lowering interleukin-1 activity with anakinra improves myocardial deformation in rheumatoid arthritis

Abstract

Objective: Inhibition of Interleukin-1 activity improves nitrooxidative stress, endothelial and coronary function. We investigated a) the association of nitrooxidative stress and endothelial function with myocardial deformation b) the effects of anakinra, an interleukin-1a receptor antagonist on myocardial deformation in patients with rheumatoid arthritis (RA).

Methods: We compared 46 RA patients to 23 normal controls. Twenty-three patients received anakinra (150mg s.c. o.d) and 23 patients a 5mg increase of prednisolone dose for 30 days. At baseline and post-treatment we assessed a) the LV longitudinal, circumferential and radial strain and strain rate, using speckle tracking echocardiography b) the coronary flow reserve (CFR) c) the flow-mediated endothelial-dependent dilation of the brachial artery (FMD) and d) nitrotyrosine (NT) and malondialdehyde blood levels.

Results: Patients had impaired baseline myocardial deformation indices compared to controls (p<0.05). CFR and NT levels were related with longitudinal strain, systolic and diastolic strain rate, circumferential strain and systolic strain rate (p<0.05). FMD was related with longitudinal and circumferential diastolic strain rate (p<0.01). Compared to baseline, anakinra-treated patients increased the longitudinal strain (-17.8 (3.7) vs. -22.1 (3.5) %), systolic (-1.02 (0.23) vs. -1.25 (0.23) l/s) and diastolic (0.96 (0.37) vs. 1.20 (0.39) l/s) longitudinal strain rate, circumferential strain and strain rate (p<0.05 for all comparisons). No significant changes were observed among prednisolone-treated patients.

Conclusions: Myocardial deformation is impaired in RA patients and is related with nitrooxidative stress and endothelial dysfunction. Chronic inhibition of IL-1 improves LV deformation in parallel with endothelial function and nitrooxidative stress.

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles