Objective: To investigate determinants of, and outcomes from, coronary angiography and intervention in patients with non-ST-segment elevation myocardial infarction (nSTEMI).
Design: Observational study.
Setting: 44 British hospitals with interventional facilities.
Patients: 13489 admissions with nSTEMI; July 2005 - December 2006.
Main outcome measures: Rate of angiography during index admission; death and readmission to hospital within 180 days.
Results: Significantly lower rates of angiography were observed for females, the elderly, the most deprived and those having cardiac, and most non-cardiac co-morbidities. Performance of angiography, compared with no angiography, was not associated with lower rate of readmission (multiple adjusted hazard ratio (HR) 0.96, 95% CI 0.74-1.24) unless accompanied by coronary intervention (HR 0.73, 95% CI 0.56-0.95). Angiography was associated with reduction in 180-day mortality for survivors of hospitalization (HR 0.59, 95% CI 0.49-0.72); with greater reduction when followed by an intervention (HR 0.34, 95% CI 0.28-0.42). This mortality benefit following intervention was seen in both females (HR 0.42, 95% CI 0.29-0.6) and males (HR 0.31, 95% CI 0.24-0.41), across age groups; <65 years, (HR 0.25, 95% CI 0.14-0.44), 65 – 79 years, (HR 0.29, 95% CI 0.22-0.39) and 80 or more years, (HR 0.52, 95% CI 0.37-0.74). Mortality benefit was not significantly attenuated by the presence of co-morbidities.
Conclusion: Performance of angiography and coronary intervention following nSTEMI was associated with mortality benefit that persisted in the presence of both cardiac and non-cardiac co-morbidities. Mortality benefit was observed across age groups and was similar for both sexes.
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